Immunogenetics of human minor histocompatibility antigens: their polymorphism and immunodominance
نویسندگان
چکیده
منابع مشابه
Human minor histocompatibility antigens.
Disparities in minor histocompatibility antigens between HLA-matched organ and bone marrow donors and recipients create a potential risk for graft failure and graft-versus-host disease. These conditions necessitate lifelong pharmacological immunosuppression of organ and bone marrow transplant recipients. Recent technical advances have resulted in the identification of the chemical nature of the...
متن کاملPolymorphism of human minor histocompatibility antigens: T cell recognition of human minor histocompatibility peptides presented by HLA- B35 subtype molecules
To investigate the polymorphism of human minor histocompatibility (mH) antigens, PBLs from 23 Japanese individuals and 25 German individuals with HLA-B35 were studied by using four human mH antigen-specific, HLA-B35-restricted CTL clones. The CTL clones killed PHA-stimulated PBLs from all 23 Japanese individuals. On the other hand, they killed the PHA-stimulated PBLs from 19 of 25 German indivi...
متن کاملMinor histocompatibility antigens.
ISTOCOMPATIBILITY antigens are a group of cell H membrane alloantigens that can trigger T-lymphocyte proliferative and/or cytolytic activity in vitro and may initiate graft rejection or graft-versus-host disease (GVHD) in vivo. AB0 and related antigens, whose presence on vascular endothelial cells may provoke antibody-mediated graft rejection, are excluded from this group because they do not in...
متن کاملHapMap scanning of novel human minor histocompatibility antigens.
Minor histocompatibility antigens (mHags) are molecular targets of allo-immunity associated with hematopoietic stem cell transplantation (HSCT) and involved in graft-versus-host disease, but they also have beneficial antitumor activity. mHags are typically defined by host SNPs that are not shared by the donor and are immunologically recognized by cytotoxic T cells isolated from post-HSCT patien...
متن کاملImmunodominance in the CTL response against minor histocompatibility antigens: interference between responding T cells, rather than with presentation of epitopes.
We have investigated mechanisms involved in immunodominance of the CTL response of C57BL/6 (B6) mice against cells of BALB.B origin. This transplantation barrier consists of at least 40 minor histocompatibility (H) Ags. Insufficient presentation of nondominant epitopes in the presence of dominant epitopes was investigated as a possible mechanism for immunodominance. Ag presentation was assessed...
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ژورنال
عنوان ژورنال: Immunogenetics
سال: 1992
ISSN: 0093-7711,1432-1211
DOI: 10.1007/bf00185109